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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone Synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone |
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الموضوع |
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كيمياء |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good antibacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene) amino]-1,5-dimethyl-2-phenyl- 1,2-dihydropyrazol-3-one (4) and [(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol- 4-ylimino)methyl] benzonitrile (5) with MIC values of 6.25 μg/mL. |
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ردمد |
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1420-3049 |
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اسم الدورية |
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Molecules |
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المجلد |
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15 |
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العدد |
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10 |
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سنة النشر |
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1431 هـ
2010 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Saturday, February 18, 2012 |
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الباحثون
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | باحث | دكتوراه | aasiri2@kau.edu.sa |
| سلمان أحمد خان | Khan, Salman A | باحث | دكتوراه | sahmad_phd@yahoo.co.in |
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